Programme
THURSDAY 17TH SEPTEMBER 2020
8:30 – 9:00
Registration
Session 1/I – Opening
9:00 – 9:15
Radislav Sedláček, IMG – Welcome – “Clustering in preclinical evaluation in the Czech Republic and Europe”
9:15 – 9:30
Jana Klánová, MUNI (remote) – Welcome – “Exposome: the interplay of external and internal factors beyond health”
9:30 – 9:45
Martin Fusek, IOCB – Welcome – IOCB
Keynote lectures – preclinical models
9:45 – 10:25
Danny Huylebroeck, Erasmus UMC – “Up and downstream of Mowat-Wilson Syndrome protein ZEB2 in mouse and cellular models”
10:25 – 11:05
Eckhard Wolf, LMU – “Genetically tailored pig models for monogenic diseases”
11:05 – 11:35
Coffee break
Sessio 1/II – From chemistry to preclinical pipeline
11:35 – 12:05
Eva Kudová, IOCB – “Steroidal Molecules As Rapid Acting Therapeutics”
12:05 – 12:35
Radim Nencka, IOCB – “Facing the crisis: modern approaches to novel antiviral compounds”
12:35 – 13:20
Lunch break
Session 1/III – Environmental part
13:20 – 13:50
Luděk Bláha, MUNI (remote) – “Mechanistic toxicology and Adverse Outcome Pathways in the current health risk assessment”
13:50 – 14:20
Pavel Babica, MUNI (remote) – “Advanced in vitro-in vivo toxicology pipelines in research of chemical safety”
Session 1/IV – Informatics
14:20 – 14:50
Liesbet Geris, Univ Liège and KU Leuven (remote) – “Connecting the genome and the phenome through in silico models”
14:50 – 15:20
Marek Ostaszewski, Uni Lux (remote) – “Visual analytics and hypothesis building in systems biomedicine using Disease Maps”
15:20 – 16:00
Coffee break + poster session
Session 1/V – Preclinical development and drug discovery
16:00 – 16:30
Jonathan Ward, Genome Biologics (remote) – “A novel approach to (cardiovascular) drug discovery?”
16:30 – 17:00
Tbc, Apigenex
Session 1/VI – Short technology talks
17:00 – 17:15
Igor Valerián, accela – “Whole Animal, In Vivo Optical Imaging: Scientific Principals and Applications”
17:15 – 17:30
Veronika Grešáková, BioVendor – “MicroRNAs – powerfull regulators and promising biomarkers”
17:30 – 17:45
Jitka Zrostlíková, HPST (Agilent distributor) – “Workflows for metabolism research using LC/MS QTOF and GC/MS QTOF analytical techniques”
17:45 – 17:48
Thomas Münch, Striatech GmbH (remote) – “Assessing disease progression with optomotor measurements in rodents”
Keynote lecture – preclinical models
17:50 – 18:30
Elizabeth Fisher, UCL (remote) – “Physiological and humanised mouse models for neurodegenerative disease”
19:00
Networking dinner – Spojovna brewery
Friday 18 September 2020
8:30 – 9:00
Registration
9:00 – 9:15
Jan Rozman, IMG – Opening of the block 2
Session 2/I – Immunology
9:15 – 9:45
Dominik Filipp (Matouš Vobořil), IMG – “Toll-like receptor signaling in thymic epithelial cells enforces immune tolerance”
9:45 – 10:15
Ondřej Štěpánek, IMG (remote) – “Differential roles of LCK in T-cell antigen receptor singaling triggered by MHCI or MHCII antigens”
10:15 – 10:45
Peter Dráber, IMG (remote) – “Regulation of TNF-induced cell death”
10:45 – 11:15
Coffee break
Session 2/II – Immunology
11:15 – 11:45
Andreas Ludwig, RWTH Aachen (remote) – “Critical trafficking and regulation of the metalloproteinase ADAM17”
11:45 – 12:15
Jana Balounová, IMG – “Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors”
12:15 – 12:45
Tomáš Stopka, 1st MF Charles Uni – “Epigenetics of leukemic stem cells and mechanisms of resistance to DNA methylation inhibitors”
12:45 – 13:30
Lunch break
Session 2/III – Neurology
13:30 – 14:00
Yann Herault, IGBMC (remote) – “Assessment of preclinical drugs to improve cognition in models for Down syndrome with a specific focus on two targets DYRK1A and CBS”
14:00 – 14:30
Karol Kaiser, Uni Basel (remote) – “Regulation of 4th ventricle choroid plexus development by Wnt5a-MEIS axis”
Session 2/IV – Immunology, genetic diseases
14:30 – 15:00
Andrzej Dziembowski, IBB (remote) – “Cytoplasmic polyadenylation as a key regulator of physiological processes”
15:00 – 15:30
Pavel Krejčí, MUNI – “Stressed cells do not talk”
15:30 – 16:00
Coffee break
16:00 – 16:30
Monica Ballarino, Uni Rome (remote) – “A comprehensive glimpse on Charme long noncoding RNA”
16:30 – 17:00
Jakub Rohlena, IBT – “Mitochondrial respiration is necessary to combat oxidative stress in quiescent cells”
Session 2/V – Flash talks
17:00 – 17:07
Barbora Procházková, 3rd MF Charles Uni – “The role of CPEB2 inhibition for the expression of the CPEB3 and CPEB4 in mammalian oocytes”
17:07 – 17:14
Josef Bodor, ILaB – “Cancer immunotherapy: rejuvenation of anti-cancer response by immune checkpoint blockade using novel multifunctional nanoparticle to block CTLA-4 and eliminate ICER”
Closing
17:15 – 17:30
Michael Raess, Infrafrontier GmbH (remote) – “INFRAFRONTIER – How we support European research communities”
17:30 – 17:45
Radislav Sedláček, IMG – Closing